化学
三环
吞吐量
赫克反应
组合化学
有机化学
催化作用
钯
电信
计算机科学
无线
作者
James R. Annand,Paul S. Riehl,Danielle M. Schultz,Corinna S. Schindler
标识
DOI:10.1021/acs.joc.0c00997
摘要
The ent-kaurenes represent a class of naturally occurring diterpenes of biological importance. Several members of the ent-kaurenes contain a common, tricyclic spirolactone core as a key structural motif. This study details a concise approach toward the development of a Mizoroki-Heck reaction to access this spirolactone core. The strategy described herein was enabled in microscale high-throughput experiments to allow for the rapid identification and optimization of superior reaction conditions.
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