生物累积
抵抗性
肠道菌群
抗生素
微塑料
生物
微生物学
磺胺甲恶唑
抗生素耐药性
化学
生物化学
生态学
整合子
作者
Jin Liu,Min Lv,Anqi Sun,Jing Ding,Yunqing Wang,Xiaofeng Chang,Lingxin Chen
出处
期刊:Chemosphere
[Elsevier]
日期:2022-05-01
卷期号:294: 133810-133810
被引量:29
标识
DOI:10.1016/j.chemosphere.2022.133810
摘要
Microplastics (MPs) have aroused a global health concern and their coexistence with antibiotics is inevitable. However, how MPs would affect the bioaccumulation and risks of antibiotics in humans remains poorly understood. Here a mouse model was used, and through dietary exposure, we observed that while the relative distributions of sulfamethoxazole (SMX) in tissues were relatively stable, MPs significantly reduced the bioaccumulation of SMX in mice tissues (liver, lung, spleen, heart and kidney). Notably, while SMX and MPs showed a differential effect, MPs could exacerbate the effects of SMX on gut microbiota and antibiotic resistance gene (ARG) profile, with the relative abundances of sulfonamide resistance genes and multidrug genes being significantly increased. We further identified that shifts in gut microbiota contributed to the changes in ARG profiles in mice. Combined, our results demonstrate that MPs reduced the bioaccumulation of SMX, but they enhanced its effects on gut microbiota and the antibiotic resistome of mice, indicating they might have high risks to humans.
科研通智能强力驱动
Strongly Powered by AbleSci AI