适应(眼睛)
蛋白质进化
进化生物学
蛋白质折叠
折叠(DSP实现)
变质岩
计算生物学
生物
古生物学
细胞生物学
遗传学
基因
神经科学
工程类
电气工程
作者
Acacia F. Dishman,Brian F. Volkman
标识
DOI:10.1016/j.tibs.2023.05.001
摘要
Metamorphic proteins switch reversibly between multiple distinct, stable structures, often with different functions. It was previously hypothesized that metamorphic proteins arose as intermediates in the evolution of a new fold – rare and transient exceptions to the ‘one sequence, one fold’ paradigm. However, as described herein, mounting evidence suggests that metamorphic folding is an adaptive feature, preserved and optimized over evolutionary time as exemplified by the NusG family and the chemokine XCL1. Analysis of extant protein families and resurrected protein ancestors demonstrates that large regions of sequence space are compatible with metamorphic folding. As a category that enhances biological fitness, metamorphic proteins are likely to employ fold switching to perform important biological functions and may be more common than previously thought.
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