上临界溶液温度
材料科学
低临界溶液温度
共聚物
复合材料
聚合物
作者
Shenglong Gan,Jiao Dong,Xian Li,Juan Wang,Longbin Chen,Yao Wang,Shiting Feng,Hao Li,Guofu Zhou
出处
期刊:ACS Macro Letters
[American Chemical Society]
日期:2023-02-20
卷期号:12 (3): 320-324
被引量:1
标识
DOI:10.1021/acsmacrolett.2c00731
摘要
Embolization is often used to block blood supply for controlling the growth of fibroids and malignant tumors, but limited by embolic agents lacking spontaneous targeting and post-treatment removal. So we first adopted nonionic poly(acrylamide-co-acrylonitrile) with an upper critical solution temperature (UCST) to build up self-localizing microcages by inverse emulsification. The results showed that these UCST-type microcages behaved with the appropriate phase-transition threshold value around 40 °C, and spontaneously underwent an expansion-fusion-fission cycle under the stimulus of mild temperature hyperthermia. Given the simultaneous local release of cargoes, this simple but smart microcage is expected to act as a multifunctional embolic agent for tumorous starving therapy, tumor chemotherapy, and imaging.
科研通智能强力驱动
Strongly Powered by AbleSci AI