神经科学
英语
基底外侧杏仁核
扁桃形结构
兴奋性突触后电位
心理学
背景(考古学)
人口
光遗传学
生物
抑制性突触后电位
医学
古生物学
环境卫生
作者
TaeHyun Kim,Dong Il Choi,Ja Eun Choi,Hoonwon Lee,Hyunsu Jung,Joo-Young Kim,Yongmin Sung,Hyo-Jin Park,Min Jung Kim,Dae Hee Han,Seung-Hee Lee,Bong‐Kiun Kaang
出处
期刊:Neuron
[Elsevier]
日期:2024-01-01
卷期号:112 (2): 201-208.e4
标识
DOI:10.1016/j.neuron.2023.10.013
摘要
Despite recent advancements in identifying engram cells, our understanding of their regulatory and functional mechanisms remains in its infancy. To provide mechanistic insight into engram cell functioning, we introduced a novel local microcircuit labeling technique that enables the labeling of intraregional synaptic connections. Utilizing this approach, we discovered a unique population of somatostatin (SOM) interneurons in the mouse basolateral amygdala (BLA). These neurons are activated during fear memory formation and exhibit a preference for forming synapses with excitatory engram neurons. Post-activation, these SOM neurons displayed varying excitability based on fear memory retrieval. Furthermore, when we modulated these SOM neurons chemogenetically, we observed changes in the expression of fear-related behaviors, both in a fear-associated context and in a novel setting. Our findings suggest that these activated SOM interneurons play a pivotal role in modulating engram cell activity. They influence the expression of fear-related behaviors through a mechanism that is dependent on memory cues.
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