坏死性下垂
顺铂
急性肾损伤
耳毒性
肾毒性
医学
曲美替尼
程序性细胞死亡
药理学
肌酐
肾
细胞凋亡
内科学
生物
化疗
MAPK/ERK通路
激酶
生物化学
细胞生物学
作者
Chithra K. Pushpan,Daniel F. Kresock,Matthew A. Ingersoll,Richard D. Lutze,Darby Keirns,William J. Hunter,Khalid Bashir,Tal Teitz
出处
期刊:Journal of The American Society of Nephrology
日期:2023-11-14
卷期号:35 (1): 22-40
被引量:20
标识
DOI:10.1681/asn.0000000000000261
摘要
Cisplatin-induced damage to the inner ear and kidneys shares similar cellular beneficial responses to AZD5438 and dabrafenib, highlighting the potential therapeutic use of these agents to treat both cisplatin-mediated kidney damage and hearing loss.
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