纳米地形
细胞骨架
肌动蛋白
细胞生物学
肌动蛋白细胞骨架
生物物理学
细胞内
生物
信号(编程语言)
转导(生物物理学)
信号转导
神经科学
生物系统
物理
计算机科学
细胞
遗传学
程序设计语言
作者
Qixin Yang,Yuchuan Miao,Parijat Banerjee,Matt J. Hourwitz,Minxi Hu,Quan Qing,Pablo A. Iglesias,John T. Fourkas,Wolfgang Losert,Peter N. Devreotes
标识
DOI:10.1073/pnas.2218906120
摘要
Cellular sensing of most environmental cues involves receptors that affect a signal-transduction excitable network (STEN), which is coupled to a cytoskeletal excitable network (CEN). We show that the mechanism of sensing of nanoridges is fundamentally different. CEN activity occurs preferentially on nanoridges, whereas STEN activity is constrained between nanoridges. In the absence of STEN, waves disappear, but long-lasting F-actin puncta persist along the ridges. When CEN is suppressed, wave propagation is no longer constrained by nanoridges. A computational model reproduces these experimental observations. Our findings indicate that nanotopography is sensed directly by CEN, whereas STEN is only indirectly affected due to a CEN-STEN feedback loop. These results explain why texture sensing is robust and acts cooperatively with multiple other guidance cues in complex, in vivo microenvironments.
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