黄体
黄体期
免疫系统
黄体溶解
卵巢
生物
男科
内科学
内分泌学
免疫学
医学
卵泡期
作者
Jiu-Hua Zhao,Shuting Zheng,Fengping Lin,Zhengchao Wang
出处
期刊:PubMed
日期:2022-06-01
卷期号:44 (3): 504-509
标识
DOI:10.3881/j.issn.1000-503x.13309
摘要
Corpus luteum,an important endocrine tissue in mammalian ovary,plays a role in the regulation of reproductive cycle and the establishment of early pregnancy.While studying the luteal development and its molecular regulation,we have discovered a variety of immune cells,such as T lymphocytes,macrophages,neutrophils,and eosinophils,in the corpus luteum.These immune cells accumulate and support luteal angiogenesis and progesterone production during the luteal development,thus participating in the regulation of luteal functions.In luteal regression,prostaglandin F2 can stimulate the production of inflammatory cytokines and chemokines,which help immune cells enter the corpus luteum and enhance the decomposition of corpus luteum through inflammatory reactions.According to our research achievements,we reviewed the roles of different types of immune cells in the development and degradation of mammalian luteal functions,aiming to further understand the biology of corpus luteum and provide a reference for the clinical manipulation of luteal functions.
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