纳米技术
商业化
纳米颗粒
混合动力系统
生物相容性
癌症治疗
纳米材料
介孔二氧化硅
材料科学
计算机科学
介孔材料
癌症
化学
业务
医学
营销
冶金
生物化学
催化作用
内科学
机器学习
作者
Carolina Salvador-Morales,Pedro M. Valencia,Anjali B. Thakkar,Edward W. Swanson,Robert Langer
摘要
Multifunctional hybrid nanoparticles combine some of the unique physical and chemical characteristics of two or more classes of materials, such as polymers, liposomes, metals, quantum dots and mesoporous silica among others, to create a versatile and robust new class of nanoparticles. Here we discuss the most recent synthetic strategies to create these hybrid systems and analyze four key design aspects: stability, encapsulation of therapeutic and imaging agents, controlled release of encapsulated agents, and biocompatibility. Through the combination of multiple nanomaterials, hybrid nanoparticles aim to expand the functionality of single-component systems, using the strengths of one material to improve on weaknesses of another. We then examine how hybrid nanoparticle platforms provide unique opportunities in cancer therapy, specifically in the treatment of multidrug resistant cancer. Finally, we discuss some of the challenges hybrid nanoparticles systems might face in their large scale synthesis and commercialization in the biopharmaceutical industry.
科研通智能强力驱动
Strongly Powered by AbleSci AI