胰岛素抵抗
定量胰岛素敏感性检查指数
餐后
超重
医学
胰岛素
糖尿病
代谢综合征
肥胖
内科学
脂肪组织
疾病
胰岛素敏感性
内分泌学
作者
Sylwia Płaczkowska,Lilla Pawlik-Sobecka,Izabela Kokot,Agnieszka Piwowar
摘要
There is a steady increase in the number of overweight and obese people worldwide and increasingly, younger people.Excess adipose tissue impairs the action of insulin, leading to insulin resistance (IR).Tissue IR is a major factor in relation to cardiovascular disease, metabolic syndrome and diabetes.Thus, it is important to recognize at the pre-disease stage with the possibility of therapeutic intervention.IR is assessed using indicators of epidemiological significance, most often calculated from fasting and postprandial glucose and insulin values, so-called indirect indicators of insulin resistance.The most commonly used parameter is the Homeostatic Model Assessment (HOMA).Although the Quantitative Insulin Sensitivity Check Index (QUICKI), Matsuda Index and the Insulin Secretion-Sensitivity Index-2 (ISSI-2) are also used, the values of these indices established for IR vary for different age, sex, populations and ethnic groups.Thus, appropriate reference values of indirect indices should be determined for such groups, and when this is precluded, data from published studies carried out on the most ethnically, socio-economically and age-matched populations should be applied.
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