医学
弹性成像
肝硬化
瞬态弹性成像
放射科
单中心
肝纤维化
核医学
纤维化
肝纤维化
超声波
接收机工作特性
内科学
胃肠病学
作者
Shereen Abdel Alem,Zeinab Abdellatif,Mahasen Mabrouk,Naglaa Zayed,Aisha Elsharkawy,Mohamed M. Khairy,Sherief Musa,Ismail Anwar,Ayman Yosry
标识
DOI:10.1007/s00261-019-02031-1
摘要
To evaluate the reliability of ARFI elastography for liver fibrosis staging and compare it to other non-invasive assessment of hepatic fibrosis (FIB-4 and APRI) in chronic HCV (CHC) patients. A single-center, prospective study included 2103 CHC patients. Liver stiffness (LS) was evaluated by TE and ARFI elastography. FIB-4 and APRI were calculated. The area under the receiver-operating characteristic curve (AUROCs) was used to assess the diagnostic performance of ARFI elastography for staging of liver fibrosis using TE as a reference standard. The best cut off values of ARFI elastography for diagnosis of ≥ F2, ≥ F3and F4 were 1.36 m/s, 1.45 m/s, and 1.7 m/s with AUROCs of 0.89, 0.94 and 0.95, respectively. ARFI elastography cut offs are lower in patients with normal ALT level compared to those with ALT level (1.1–< 3 ULN) and those with ALT level ≥ 3ULN (1.35 m/s vs 1.39 m/s vs 1.54 for F ≥ 2, 1.44 m/s vs 1.58 m/s vs 1.6 m/s for F3, 1.69 m/s, 1.84 m/s, 1.86 m/s for F4). FIB-4 (0.82–0.86) and APRI (0.78–0.82) yielded lower AUC in prediction of significant fibrosis and cirrhosis than ARFI elastography (0.89–0.95). ARFI elastography is a reliable method for non-invasive staging of liver fibrosis in CHC patients when compared to TE with a good diagnostic performance comparable to FIB-4 and APRI scores for the prediction of significant fibrosis and cirrhosis.
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