化学
醛
吡啶
氨基吡啶
异氰
烯酮
区域选择性
吡啶
分子内力
炔烃
废止
吲哚嗪
有机化学
药物化学
组合化学
催化作用
作者
Kasiviswanadharaju Pericherla,Pinku Kaswan,Khima Pandey,Anil Kumar
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2015-02-26
卷期号:47 (07): 887-912
被引量:171
标识
DOI:10.1055/s-0034-1380182
摘要
Advances in the last decade for the synthesis of the imidazo[1,2-a]pyridine scaffold from various substrates employing approaches such as multicomponent reactions, tandem processes, rearrangement reactions, inter- and intramolecular oxidative/reductive cyclizations, and transition-metal-catalyzed C–H activation are summarized in this review. The mechanisms for the selected transformations are also discussed. 1 Introduction 2 From 2-Aminopyridines 2.1 Revisiting Traditional Cyclocondensation 2.1.1 Regioselectivity in Cyclocondensation 2.2 Reactions of Carbonyl Compounds 2.3 Reactions of α,β-Unsaturated Carbonyl Compounds 2.4 Reactions of Nitroolefins 2.5 Reactions of Alkynes 2.6 Multicomponent Reactions 2.6.1 Three-Component Reaction of Aldehyde, 2-Aminopyridine, and Isocyanide 2.6.2 Three-Component Reaction of 2-Aminopyridine, Aldehyde, and Alkyne 2.6.3 Other Multicomponent Procedures 2.7 Reactions of N-Substituted 2-Aminopyridines 2.8 Miscellaneous Reactions 3 From Pyridines 3.1 Multicomponent Reactions 4 From Pyridinium Salts 5 From Imidazoles 5.1 Reactions of Heterocyclic Ketene Aminals 6 Miscellaneous Methods 7 Conclusion
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