化学
抑制性突触后电位
乙酰胆碱受体
烟碱激动剂
天然产物
乙酰胆碱
立体化学
烟碱乙酰胆碱受体
受体
生物化学
药理学
神经科学
医学
生物
作者
Naoki Toyooka,Da‐Yang Zhou,Soushi Kobayashi,Hiroshi Tsuneki,Tsutomu Wada,Hideki Sakai,Hideo Nemoto,Toshiyasu Sasaoka,Yasuhiro Tezuka,null Subehan,Shigetoshi Kadota,H. Martin Garraffo,Thomas F. Spande,John W. Daly
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2008-01-01
卷期号:2008 (1): 61-64
被引量:12
标识
DOI:10.1055/s-2007-1000831
摘要
Syntheses of the structures postulated for 179 and 207E, members of a proposed new class of poison-frog alkaloids, 6,7-dehydro-5,8-disubstituted indolizidines, are described. The FT-IR spectrum and GC retention time of the synthetic 207E were different from those of the natural product; consequently the original structure of 207E needs to be revised. It is likely that the position of the double bond is instead at the 7,8-position.
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