神经科学
小胶质细胞
疾病
生物神经网络
发病机制
阿尔茨海默病
神经元
平衡(能力)
生物
医学
炎症
病理
免疫学
作者
Christopher M. Henstridge,Bradley T. Hyman,Tara L. Spires‐Jones
标识
DOI:10.1038/s41583-018-0113-1
摘要
The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but neurons do not work in isolation. Emerging evidence suggests that the intricate balance of interactions between neurons, astrocytes, microglia and vascular cells required for healthy brain function becomes perturbed during the disease, with early changes likely protecting neural circuits from damage, followed later by harmful effects when the balance cannot be restored. Moving beyond a neuronal focus to understand the complex cellular interactions in Alzheimer disease and how these change throughout the course of the disease may provide important insight into developing effective therapeutics.
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