热休克蛋白90
化学
热休克蛋白
伴侣(临床)
结合位点
热休克蛋白70
对接(动物)
生物化学
Hsp90抑制剂
立体化学
基因
医学
护理部
病理
作者
Tae‐Ho Lee,Young Ho Seo
标识
DOI:10.1016/j.bmcl.2013.09.050
摘要
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays an important role in regulating the maturation and stabilization of many oncogenic proteins. In an attempt to discover a new class of Hsp90 inhibitors, a series of 1,3,5-triazine compounds were rationally designed, synthesized, and their biological activities were evaluated. Compound 3b was found to degrade Hsp90's client proteins of Her2, Met and Akt and to induce the expression level of Hsp70. The binding mode of 3b in the ATP-binding site of Hsp90 was predicted by the molecular docking.
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