Hydrophobia chromatography was used for the first time to purify phycobiliproteins. A method of phycocyanin production from the blue-green alga Spirulina platensis (Nordst.) Geitl. is proposed. The method includes isoelectric precipitation of proteins at pH Ј 4, production of the phycocyanin fraction I from the supernatant liquid, of the fraction II - from the sediment after its water-washing at pH < 4, and also subsequent purification by hydrophobic chromatography.