寨卡病毒
病毒学
肽
生物
细胞毒性
抗菌剂
病毒
病毒包膜
微生物学
体外
生物化学
作者
Weichen Xiong,Jingyan Li,Yifei Feng,Jinwei Chai,Jiena Wu,Yunrui Hu,Maolin Tian,Weicong Lu,Xueqing Xu,Min Zou
出处
期刊:Viruses
[MDPI AG]
日期:2021-11-28
卷期号:13 (12): 2382-2382
被引量:9
摘要
Several years have passed since the Zika virus (ZIKV) pandemic reoccurred in 2015-2016. However, there is still a lack of proved protective vaccines or effective drugs against ZIKV. The peptide brevinin-2GHk (BR2GK), pertaining to the brevinin-2 family of antimicrobial peptides, has been reported to exhibit only weak antibacterial activity, and its antiviral effects have not been investigated. Thus, we analyzed the effect of BR2GK on ZIKV infection. BR2GK showed significant inhibitory activity in the early and middle stages of ZIKV infection, with negligible cytotoxicity. Furthermore, BR2GK was suggested to bind with ZIKV E protein and disrupt the integrity of the envelope, thus directly inactivating ZIKV. In addition, BR2GK can also penetrate the cell membrane, which may contribute to inhibition of the middle stage of ZIKV infection. BR2GK blocked ZIKV E protein expression with an IC50 of 3.408 ± 0.738 μΜ. In summary, BR2GK was found to be a multi-functional candidate and a potential lead compound for further development of anti-ZIKV drugs.
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