Metal - based curcumin and quercetin complexes: cell viability, ROS production and antioxidant activity

化学 槲皮素 姜黄素 活力测定 抗氧化剂 DPPH 活性氧 MTT法 核化学 多酚 生物化学 细胞生长 细胞
作者
Ergül Mutlu Altundağ,Cahit Özbilenler,Selma Ustürk,Namık Refik Kerküklü,Masoud Afshani,Elvan Yilmaz
出处
期刊:Journal of Molecular Structure [Elsevier BV]
卷期号:1245: 131107-131107 被引量:26
标识
DOI:10.1016/j.molstruc.2021.131107
摘要

Flavonoids, also known as polyphenols, contain carbonyl and hydroxyl groups and are capable of forming complexes with metal ions. In this perspective, complexation of curcumin and quercetin were achieved by using magnesium and calcium divalent cations to enhance the solubilities of curcumin and quercetin. The cell proliferation and antioxidant effects were tested on colon carcinoma cells (HCT-116). Metal complexes of curcumin and quercetin were characterized using XRD analysis, TOF mass spectrometry, FT-IR and UV-Vis spectroscopies. A solubility assay was conducted to demonstrate the improvements in the solubility of curcumin and quercetin. Cell viability was measured by cell viability detection kit-8 (CVDK-8) and imaged by crystal violet assay. 2′,7′-dichlorodihydrofluorescein diacetate fluorogenic (DCFH-DA) dye was used to determine intracellular reactive oxygen species (ROS) production. Radical scavenging activity of metal complexes were analyzed by 2,2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH) assay. Cell viability, reactive oxygen species (ROS) production assays reveal that curcumin and its complexes showed better antiproliferative effect at lower concentrations compared to quercetin complexes. In contrast, quercetin complexes had better radical scavenging activity compared to curcumin complexes based upon DPPH assay. Metal complexes of curcumin and quercetin can be useful to elucidate alternative strategies in cancer prevention and therapy by enhancing their solubilities.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Volta发布了新的文献求助30
刚刚
糊涂的皮卡丘完成签到 ,获得积分10
1秒前
3秒前
洪星发布了新的文献求助10
3秒前
张光光发布了新的文献求助10
4秒前
7秒前
冷酷的树叶完成签到 ,获得积分10
8秒前
9秒前
10秒前
12秒前
Lifetour发布了新的文献求助10
12秒前
12秒前
animenz完成签到,获得积分10
13秒前
GOD伟完成签到,获得积分0
14秒前
14秒前
dr_chou发布了新的文献求助10
16秒前
小七发布了新的文献求助10
16秒前
张博发布了新的文献求助10
19秒前
破晓应助Lifetour采纳,获得10
19秒前
19秒前
脑洞疼应助一块小饼干采纳,获得10
20秒前
21秒前
丁满完成签到,获得积分10
21秒前
重要达应助青柠大大采纳,获得30
22秒前
孙兴燕完成签到,获得积分10
22秒前
Orange应助读书的时候采纳,获得10
23秒前
23秒前
CipherSage应助务实孤丝采纳,获得10
23秒前
24秒前
dr_chou完成签到,获得积分10
25秒前
虔三愿发布了新的文献求助10
26秒前
29秒前
碧蓝巧荷发布了新的文献求助10
29秒前
30秒前
31秒前
Jasper应助给爷冲奶粉采纳,获得10
32秒前
Aries完成签到 ,获得积分10
36秒前
momo完成签到,获得积分20
36秒前
37秒前
37秒前
高分求助中
【请各位用户详细阅读此贴后再求助】科研通的精品贴汇总(请勿应助) 10000
International Code of Nomenclature for algae, fungi, and plants (Madrid Code) (Regnum Vegetabile) 1000
Robot-supported joining of reinforcement textiles with one-sided sewing heads 530
航空发动机三维数值仿真 500
Apiaceae Himalayenses. 2 500
Beyond The Sentence: Discourse And Sentential Form 500
Maritime Applications of Prolonged Casualty Care: Drowning and Hypothermia on an Amphibious Warship 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4073256
求助须知:如何正确求助?哪些是违规求助? 3612119
关于积分的说明 11468013
捐赠科研通 3331452
什么是DOI,文献DOI怎么找? 1831249
邀请新用户注册赠送积分活动 901272
科研通“疑难数据库(出版商)”最低求助积分说明 820227