葛根素
神经保护
半影
缺血
药理学
医学
再灌注损伤
炎症
脂质体
脑缺血
化学
麻醉
血脑屏障
免疫学
病理
中枢神经系统
内科学
生物化学
替代医学
作者
Wei Liu,Haowei Lu,Xiao-Yong Rao,Xiang Li,Hongdan Lu,Feifei Li,Yan He,Riyue Yu,Rongsheng Zhong,Yao Zhang,Xingguang Luο,Hongliang Xin
出处
期刊:Nano Research
[Springer Nature]
日期:2021-03-27
卷期号:14 (12): 4634-4643
被引量:14
标识
DOI:10.1007/s12274-021-3395-y
摘要
The recovery of blood circulation following cerebral infarction-associated thrombolysis brings new damage to the brain, which is cerebral ischemia-reperfusion injury (CIRI). Inflammation is the main pathological mechanism of CIRI. The inflammatory response triggered by cerebral ischemia-reperfusion provides neutrophils with a special opportunity to facilitate drug delivery to the site of ischemic penumbra through the chemotaxis of inflammatory factors by neutrophils. Puerarin is an isoflavone derivative with a significant neuroprotective effect in vitro. But the blood-brain barrier (BBB) impedes its therapeutic efficacy on CIRI within the brain. Inspired by the pathological process, we have used neutrophils as carriers to enhance the BBB penetration of liposomes loaded with puerarin and improve the concentration of puerarin in the brain parenchyma in this study. These results showed that puerarin-containing liposomes were released in response to inflammatory conditions associated with brain injury to enhance the neuroprotection effect at the ischemic penumbra.
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