NiFe2O4 nanoparticle modified electrochemical sensor for the voltammetric study of folic acid and paracetamol

In this work, nickel ferrite nanoparticles (NiFe2O4) were prepared from metal nitrates and capping agent by thermal treatment followed by grinding and calcination, and characterized using powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), and Fourier transform infrared spectroscopy (FTIR). The prepared NiFe2O4 was used for the modification of the carbon paste electrode (CPE). The Electrochemical behavior of the NiFe2O4 modified CPE (NiFe-CPE) for the folic acid (FA) and paracetamol (PC) was investigated using the voltammetric method. The scan rate effect on NiFe-CPE was studied individually for FA and PC, and found to be a diffusion-controlled electrode process. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.39 and 1.3 μM for FA and 0.08 and 0.26 μM for PC, respectively, at the NiFe-CPE. In addition, the performance of the NiFe-CPE for the simultaneous determination of FA and PC was studied. The NiFe-CPE has shown high stability and reproducibility towards the PC compared to FA. Moreover, the prepared sensor was efficiently applied to detect the FA and PC in pharmaceutical samples.