氢酰化
组合化学
化学
可扩展性
反应条件
有机化学
计算机科学
催化作用
醛
数据库
作者
Thomas Varlet,Damien Bouchet,Elsa Van Elslande,Géraldine Masson
标识
DOI:10.1002/chem.202201707
摘要
We report herein a convenient and scalable dearomative hydroacylation reaction of indoles. Employing readily available aldehydes as the acyl source and TBADT as an inexpensive direct HAT photocatalyst, a variety of indoles derivatives were converted into synthetically interesting 2-acylindolines in good to excellent yields as well as great diastereoselectivity under mild conditions. An asymmetric version of the reaction was successfully developed and an experimental mechanistic investigation was carried out in order to gain further insights on the assumed reaction pathway.
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