生物膜
组织粘连
粘附
聚丙烯酸
材料科学
聚丙烯酰胺
傅里叶变换红外光谱
伤口敷料
化学
伤口愈合
化学工程
胶粘剂
抗菌剂
慢性伤口
自愈水凝胶
生物医学工程
纳米技术
聚合物
高分子化学
细菌
复合材料
医学
外科
生物
有机化学
图层(电子)
工程类
遗传学
作者
Yanling Peng,Zefeng Wang,Yan Zhou,Feiying Wang,Shengnan Zhang,Dinggeng He,Le Deng
标识
DOI:10.1016/j.msec.2021.112111
摘要
Bacterial infection is a common phenomenon in the process of postoperative wound healing. In severe cases, it may even lead to life-threatening, which brings a heavy burden to the clinical treatment and causes huge losses to the society and economy. As one of the most commonly applied medical materials for wound treatment, hydrogel dressings are mainly used to cover and protect wounds and provide a favorable environment to facilitate wound healing. In this work, we developed an antibacterial hydrogel dressing (Fc-PAAM) with high adhesion, which is consisted of polyacrylamide (PAM) hydrogel framework and polyacrylic acid-functionalized (PAA) with ferrocene (Fc). Morphology, adhesion and pressure resistance of PAAM hydrogel were confirmed by using scanning electron microscope (SEM) and universal testing machine, and Fc decoration in the hydrogel network was well demonstrated by using Fourier transform infrared spectroscopy (FT-IR). Ultraviolet-visible spectroscopy (UV–vis) displayed that the Fc-PAAM hydrogel had excellent peroxidase-like activity as well. It not only exhibited prominent antimicrobial activity against Gram (+/−) bacteria, but also performed high efficiency in preventing the formation of biofilms. In addition, in vivo experiments indicated that this adhesive dressing could significantly prevent bacterial infections. Compared with other clinical treatment methods, this kind of hydrogel is not easy to cause bacterial resistance, and the used raw materials are easy to obtain and low in price, which can amplify the antibacterial properties of H2O2 and provide a new opportunity for the treatment of clinical bacterial infections.
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