生物相容性
材料科学
自愈水凝胶
自愈
伤口愈合
生物医学工程
壳聚糖
纳米技术
体内
抗菌活性
广谱
化学工程
组合化学
医学
高分子化学
外科
化学
冶金
生物技术
替代医学
病理
细菌
工程类
生物
遗传学
作者
Leqing Fan,Zhongjie He,Xue-Liang Peng,Junshan Xie,Fangfang Su,Daixu Wei,Yaping Zheng,Dongdong Yao
标识
DOI:10.1021/acsami.1c14216
摘要
Torealize intelligent and personalized medicine, it is a huge challenge to develop a hydrogel dressing that can be used as a sensor to monitor human health in real-time while promoting wound healing. Herein, an injectable, self-healing, and conductive chitosan-based (CPT) hydrogel with pH responsiveness and intrinsic antibacterial properties was fabricated via a Schiff base linkage and a hydrogen bond. Due to the introduction of Schiff base bonds, the injectable CPT hydrogel exhibits various excellent properties, such as pH responsiveness to sol-gel transition, self-healing properties, and broad-spectrum antibacterial properties even without additional antibacterial agents. In vitro experiments verify the excellent biocompatibility of the as-prepared hydrogel. An in vivo experiment in a mouse full-thickness skin-wound model was performed to confirm the outstanding effect on wound healing. Meanwhile, as epidermal sensors, the conductive hydrogel that perceives various human activities in real-time could provide the real-time analysis of the patient's healthcare information. Based on these excellent properties, the CPT hydrogel, as a biological dressing with a sensing function, lays a solid foundation for the further realization of personalized medicine.
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