猪繁殖与呼吸综合征病毒
生物
发病机制
细胞凋亡
信号转导
机制(生物学)
免疫学
细胞生物学
病毒学
病毒
遗传学
认识论
哲学
出处
期刊:Virus Genes
[Springer Nature]
日期:2019-04-19
卷期号:55 (4): 433-439
被引量:8
标识
DOI:10.1007/s11262-019-01665-z
摘要
Porcine reproductive and respiratory syndrome virus (PRRSV) is the etiologic agent of porcine reproductive and respiratory syndrome (PRRS), a devastating disease of swine that poses a serious threat to the swine industry worldwide. The induction of apoptosis in host cells is suggested to be the key cellular mechanism that contributes to the pathogenesis of PRRS. Various signaling pathways have been identified to be involved in regulating PRRSV-induced apoptosis. In this review, we summarize the potential signaling pathways that contribute to PRRSV-induced apoptosis, and propose the issues that need to be addressed in future studies for a better understanding of the molecular basis underlying the pathogenesis of PRRS.
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