镇静剂
止痛药
药理学
消炎药
体内
镇静
伤害
炎症
医学
催眠药
传统医学
萜烯
镇静剂/催眠药
化学
生物
免疫学
受体
内科学
生物化学
生物技术
出处
期刊:Cellular and Molecular Biology
日期:2019-04-30
卷期号:65 (4): 37-42
被引量:7
标识
DOI:10.14715/cmb/2019.65.4.6
摘要
Inflammation and insomnia are two types of symptoms very likely occur in life, seriously perplexing people's work and life. How to alleviate these symptoms is an urgent medical problem. Lucidone D (LUC) is a terpene from the ethanol extract of Ganoderma lucidum fruiting body. Triterpenoids are also the main pharmacological components of Ganoderma lucidum. In recent years, people pay more and more attention to its anti-inflammatory effect. In this study, LPS induced RAW264.7 macrophage inflammatory response model was used to evaluate the anti-inflammatory activity of LUC. The results showed that LUC could significantly inhibit the production of inflammatory mediators NO, which may play a role by down-regulating the expression level of iNOS and COX-2 proteins. Meanwhile, the production of TNF-α and IL-6 was significantly inhibited. These results indicate that LUC has obvious anti-inflammatory activity. Writhing and sedation tests in ICR male mice showed that LUC showed significant analgesic and sedative effects. In conclusion, these results suggest the anti-inflammatory, analgesic and sedative effects of LUC in vitro and in vivo.
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