胚胎干细胞
脂质代谢
体外
新陈代谢
双酚
细胞生物学
胚状体
化学
生物
发育毒性
细胞分化
生物化学
遗传学
基因
诱导多能干细胞
胎儿
环氧树脂
有机化学
怀孕
作者
Xiaoxing Liang,Renjun Yang,Nuoya Yin,Francesco Faiola
标识
DOI:10.1016/j.jhazmat.2020.124387
摘要
The widely used chemical bisphenol A (BPA) has been associated with several health effects. In recent years, many derivatives were developed to replace BPA although without thorough toxicological evaluation. Here, we employed a human embryoid body (EB)-based in vitro global differentiation and hepatic specification models, followed by RNA-seq analyses, to comprehensively study the potential developmental toxicity of six BPA replacements (BPS, BPF, BPZ, BPB, BPE, and BPAF), as compared to BPA. We found that those bisphenols may disrupt lineage commitment and lipid metabolism during early embryonic development. These effects mostly manifested via the dysregulation of HOX and APO family genes. Moreover, among the seven bisphenols analyzed, BPE seemed to have the mildest effects.
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