Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis
控制释放
纳米技术
生物相容性
纳米载体
作者
W. Zhao,Hua Wang,Haimang Wang,Ying Han,Zhibo Zheng,Xudong Liu,Bin Feng,Hongyu Zhang
出处
期刊:Nanoscale [The Royal Society of Chemistry] 日期:2021-04-09卷期号:13 (13): 6394-6399被引量:13
标识
DOI:10.1039/d0nr08887k
摘要
Visible light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement were constructed by supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles (bMSNs-AZO) and β-cyclodextrin-modified poly(2-methacryloyloxyethyl phosphorylcholine) (CD-PMPC). Visible light could effectively trigger azobenzene isomerization and thus induce drug release after passing through the dermal tissue. Additionally, the hydration layer formed by CD-PMPC on the surface of the nanoparticles played an important role in lubrication enhancement, which was beneficial for the treatment of osteoarthritis.