In situ mineralization of nano-hydroxyapatite on bifunctional cellulose nanofiber/polyvinyl alcohol/sodium alginate hydrogel using 3D printing

聚乙烯醇 热重分析 化学工程 纳米纤维 水溶液 傅里叶变换红外光谱 自愈水凝胶 材料科学 纤维素 高分子化学 化学 复合材料 有机化学 工程类
作者
Ragab E. Abou-Zeid,Ramzi Khiari,Ahmed Salama,Mohamed A. Diab,Davide Beneventi,Alain Dufresne
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:160: 538-547 被引量:67
标识
DOI:10.1016/j.ijbiomac.2020.05.181
摘要

This paper reports the manufacturing by 3D printing of scaffolds for in-situ mineralization of hydroxyapatite using aqueous suspensions of alginate and polyvinyl alcohol (PVA)-grafted cellulose nanofibers (CNF). Bifunctional CNF with carboxyl and aldehyde moieties were prepared from bleached bagasse pulp and crosslinked with PVA. Aqueous hydrogels for 3D printing were prepared by directly mixing PVA-grafted CNF with sodium alginate, with and without the addition of phosphate ions. A calcium chloride solution was sprayed during the printing process in order to partially crosslink alginate and to increase the dimensional stability of the printed gel. At the end of the printing process, the prepared scaffolds were dipped into a CaCl2 solution to: i) complete alginate crosslinking and ii) promote hydroxyapatite nucleation and growth by reaction with phosphate ions. In order to better understand the mechanisms governing manufacturing of scaffolds by 3D printing, the rheological behavior of alginate/PVA-grafted CNF and the mechanical properties of unit filaments obtained by direct hydrogel extrusion were investigated. The final scaffolds were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). This study shows that 3D printed sodium alginate/PVA-grafted CNF hydrogels are promising scaffold materials for bone tissue engineering.
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