A randomized controlled clinical trial of full-spectrum endoscopy versus conventional colonoscopy for the diagnosis of colonic polyps

Objective To evaluate the diagnostic efficiency of full-spectrum endoscopy(FUSE) versus conventional colonoscopy for colonic polyps and adenoma. Methods Patients who underwent colonoscopy were randomly allotted into two groups according to randomization and self-control criteria. Patients in group A underwent conventional endoscopy firstly and then to FUSE. Patients in group B were opposite performed the examinations. The polyps and adenomatous polyps were resected or biopsied for pathological examination. Miss rate of colonic polyps as well as adenomatous polyps was calculated. Results A total of 100 patients were recruited for the study, including 45 in group A and 55 in group B. FUSE was significantly superior compared to conventional endoscopy with lower miss rate of polyps (6.52% VS 34.04%, χ2=17.685, P=0.000) as well as adenomatous polyps (5.00% VS 34.38%, χ2=11.774, P=0.001). For the first endoscopic examination, the adenomatous polyps which were found out by FUSE were more than that of ordinary colonoscopy in the right colon (χ2=5.153, P=0.023). The size of adenoma found by ordinary colonoscopy and FUSE was no statistically different whether in the first (t=0.334, P=0.739) or second (t=1.297, P=0.219) endoscopic examinations. Conclusion FUSE is useful to improve the quality of endoscopic examination because of its broad view-field. Key words: Colonoscopy; Full-spectrum endoscopy; Intestinal polyps; Adenoma