内科学
内分泌学
氧化应激
医学
炎症
脂肪肝
肝损伤
组织病理学
维生素E
抗氧化剂
维生素C
生物
病理
生物化学
疾病
作者
Fariba Aghaei,Alexei Wong,Mehdi Zargani,Amir Sarshin,Foad Feizolahi,Zahra Derakhshan,Mohammadreza Hashemi,Ehsan Arabzadeh
出处
期刊:Nutrition
[Elsevier]
日期:2023-11-01
卷期号:115: 112167-112167
被引量:2
标识
DOI:10.1016/j.nut.2023.112167
摘要
The aim of this study was to demonstrate that swimming exercise combined with silymarin and vitamin C supplementation improves hepatic inflammation, oxidative stress, and liver histopathology in elderly rats with high-fat diet-induced liver damage.Forty elderly male Wistar rats were randomly assigned to five groups (n = 8 in each): a normal diet (control), a high-fat diet (HFD), HFD + silymarin and vitamin C supplementation (HFD+Sup), HFD + swimming exercise (HFD+Exe), and HFD+Sup+Exe group (HFD+Sup+Exe). The non-alcoholic fatty liver model was induced for 6 wk in the HFD groups. After 6 wk of consuming an HFD, a daily supplemental gavage was administered to rats as an intervention along with HFD in the supplement groups for 8 wk. Moreover, rats in the exercise groups were subjected to swimming exercise training 5 d/wk for the same period.The combination of swimming training and supplementation caused significant decreases in liver inflammatory biomarkers tumor necrosis factor-α and interleukin-1β while increasing total antioxidant capacity and peroxisome proliferator-activated receptor α (P < 0.05).In elderly rats with liver injury caused by an HFD, the combination of exercise and silymarin with vitamin C supplementation effectively reduced oxidative stress, liver inflammation, fat accumulation, and regulated liver enzymes.
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