医学
血脑屏障
药物输送
癫痫
药品
中枢神经系统
神经科学
重症监护医学
药理学
内科学
纳米技术
材料科学
心理学
精神科
作者
Meenakshi Dhanawat,. Garima,Kashish Wilson,Sumeet Gupta,Rishabh Chalotra,Nidhi Gupta
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2024-01-24
卷期号:21
标识
DOI:10.2174/0115672018266501231207095127
摘要
Abstract: Although the brain is very accessible to nutrition and oxygen, it can be difficult to deliver medications to malignant brain tumours. To get around some of these issues and enable the use of therapeutic pharmacological substances that wouldn't typically cross the blood-brain barrier (BBB), convection-enhanced delivery (CED) has been developed. It is a cutting-edge strategy that gets beyond the blood-brain barrier and enables targeted drug administration to treat different neurological conditions such as brain tumours, Parkinson's disease, and epilepsy. Utilizing pressure gradients to spread the medicine across the target area is the main idea behind this diffusion mechanism. Through one to several catheters positioned stereotactically directly within the tumour mass, around the tumour, or in the cavity created by the resection, drugs are given. This method can be used in a variety of drug classes, including traditional chemotherapeutics and cutting-edge investigational targeted medications by using positive-pressure techniques. The drug delivery volume must be optimized for an effective infusion while minimizing backflow, which causes side effects and lowers therapeutic efficacy. Therefore, this technique provides a promising approach for treating disorders of the central nervous system (CNS).
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