孟德尔随机化
医学
置信区间
优势比
全基因组关联研究
内科学
结直肠癌
单核苷酸多态性
遗传学
基因型
癌症
生物
遗传变异
基因
作者
Yin Zhang,Jiaying Wang,Mingyu Zheng,Hongchen Qu,Shuyu Yang,Fuzhou Han,Nan Yang,Wenqiang Li,Jing Qu
出处
期刊:Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2024-01-05
卷期号:103 (1): e36867-e36867
被引量:1
标识
DOI:10.1097/md.0000000000036867
摘要
We performed a bidirectional 2-sample Mendelian randomization (MR) design to explore the causal relation between telomere length (TL) and colorectal polyps. Genome-wide association study summary data of TL and colorectal polyps were extracted from the IEU open genome-wide association study database. Single nucleotide polymorphisms were served as instrumental variables at the significance threshold of P < 5 × 10-8. The inverse variance weighted method, MR-Egger method, and weight median method were performed for causal estimation in MR. Cochran Q test, MR-Egger intercept test, and leave-one-out analyses were performed to evaluate the pleiotropy of the MR results. One hundred and twenty-four single nucleotide polymorphisms were selected as instrumental variables. We found significant casual association between TL and colorectal polyps. Long TL increased the risk of colorectal polyps using the inverse variance weighted method [ukb-a-521: odds ratio (OR): 1.004, 95% confidence interval (CI): 1.001-1.007, P = .004; ukb-d-D12: OR: 1.008, CI: 1.004-1.012, P < .001; finn-b-CD2_BENIGN_COLORECANI_EXALLC2: OR: 1.170, CI: 1.027-1.332, P = .018]. Sensitivity analyses validated that the causality between TL and colorectal polyps was robust. The study provided a causal association between TL and colorectal polyps which indicated that TL might be served as a potential biomarker of colorectal polyps for screening and prevention. Nonetheless, the conclusions need further validation.
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