脂质运载蛋白
免疫系统
背景(考古学)
下调和上调
血管生成
癌症研究
生物
癌症
乳腺癌
免疫学
细胞
细胞生物学
基因
内分泌学
遗传学
古生物学
作者
Yuxiang Bao,Zhongliang Yan,Nan Shi,Xiaofeng Tian,Jiayang Li,Taolang Li,Xiaoming Cheng,Junyuan Lv
标识
DOI:10.1016/j.biopha.2023.116091
摘要
Lipocalin 2 (LCN2) is a secreted glycoprotein that is produced by immune cells, including neutrophils and macrophages. It serves various functions such as transporting hydrophobic ligands across the cellular membrane, regulating immune responses, keeping iron balance, and fostering epithelial cell differentiation. LCN2 plays a crucial role in several physiological processes. LCN2 expression is upregulated in a variety of human diseases and cancers. High levels of LCN2 are specifically linked to breast cancer (BC) cell proliferation, apoptosis, invasion, migration, angiogenesis, immune regulation, chemotherapy resistance, and prognosis. As a result, LCN2 has gained attention as a potential therapeutic target for BC. This article offered an in-depth review of the advancement of LCN2 in the context of BC occurrence and development.
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