缺氧(环境)
医学
骨愈合
中医药
机制(生物学)
干预(咨询)
伤口愈合
生物信息学
疾病
重症监护医学
外科
病理
替代医学
精神科
生物
认识论
哲学
有机化学
化学
氧气
作者
Wenxian Zhang,Feng‐Qing Yang,Qing Yan,Jiahui Li,Xiaogang Zhang,Yiwei Jiang,Jianye Dai
标识
DOI:10.1016/j.chmed.2023.09.006
摘要
As a common clinical disease, fracture is often accompanied by pain, swelling, bleeding as well as other symptoms and has a high disability rate, even threatening life, seriously endangering patients' physical and psychological health and quality of life. Medical practitioners take many strategies for the treatment of fracture healing, including Traditional Chinese Medicine (TCM). In the early stage of fracture healing, the local fracture is often in a state of hypoxia, accompanied by the expression of hypoxia inducible factor-1α (HIF-1α), which is beneficial to wound healing. Through literature mining, we thought that hypoxia, HIF-1α and downstream factors affected the mechanism of fracture healing, as well as dominated this process. Therefore, we reviewed the local characteristics and related signaling pathways involved in the fracture healing process and summarized the intervention of TCM on these mechanisms, in order to inspirit the new strategy for fracture healing, as well as elaborate on the possible principles of TCM in treating fractures based on the HIF molecular mechanism.
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