Synergistic Comprehensive Activation Methods for Dual‐Modality PDT and Hypoxia‐Triggered Chemotherapy Guided by NIR‐II Imaging beyond 1700 nm in Deep Tumors

levels in the tumor microenvironment, effectively catalyzing chemiluminescence-assisted PDT. Moreover, PDT aggravates tumor hypoxia, which in turn activates the hypoxia-activatable prodrugs like tirapazamine, resulting in a synergistic antitumor effect. With NIR-IIc imaging-guided dual-modality PDT, this study introduces a groundbreaking approach that unites Type I/II PDT with chemotherapy, significantly advancing the precise and effective treatment of deep hypoxic tumors.