The role of γδ T cells in flavivirus infections: Insights into immune defense and therapeutic opportunities

γδ T cells are a unique subset of unconventional T cells and an important component of the innate immune system. Unlike conventional αβ T cells, γδ T cells can respond rapidly during the early stages of infection, and their antigen recognition is not restricted by MHC molecules. These distinctive features underscore the important role of γδ T cells in viral clearance and infection control. Therefore, γδ T cell-based immunotherapies have been extensively explored for the treatment of a variety of diseases, including viral infections and cancers. Several therapeutic strategies based on γδ T cells have advanced to clinical trials, demonstrating promising safety and efficacy. Currently, there are no effective treatments for flavivirus infections, which are typically characterized by acute onset. Research has shown that γδ T cells can rapidly expand during the early phases of flavivirus infections and effectively suppress viral replication, making them an attractive target for the development of novel therapies for flavivirus infections. This review aims to highlight the immunological roles of γδ T cells in flavivirus infections and to explore the potential of γδ T cell-based therapeutic strategies for the prevention and treatment of these infections.