肽合成
肽
组合化学
树枝状大分子
固相合成
哌啶
化学
试剂
相(物质)
立体化学
有机化学
生物化学
作者
Hippolyte Personne,Thissa N. Siriwardena,Sacha Javor,Jean‐Louis Reymond
出处
期刊:ACS omega
[American Chemical Society]
日期:2023-01-23
卷期号:8 (5): 5050-5056
被引量:2
标识
DOI:10.1021/acsomega.2c07861
摘要
Herein, we report dipropylamine (DPA) as a fluorenylmethyloxycarbonyl (Fmoc) deprotection reagent to strongly reduce aspartimide formation compared to piperidine (PPR) in high-temperature (60 °C) solid-phase peptide synthesis (SPPS). In contrast to PPR, DPA is readily available, inexpensive, low toxicity, and nonstench. DPA also provides good yields in SPPS of non-aspartimide-prone peptides and peptide dendrimers.
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