Chitosan nanoparticles and based composites as a biocompatible vehicle for drug delivery: A review

The shellfish processing industry is one of the largest growing industries across the globe with a market size of around USD 62B. However, it also leads to a significant environmental issue as it produces >80,000 tons of waste shells globally. Unfortunately, the slow degradation of this waste causes it to accumulate over time, posing a serious threat to the marine environment. The key solution to this problem is to recycle this sea waste into a valuable product like chitin which is further used to produce chitosan. Chitosan is a natural biopolymeric substance obtained via N-deacetylation of the chitin. The chitosan-based nanoparticles are further useful for the fabrication of biopolymeric nanocomposites which are used in various biomedical applications specifically in drug delivery. Here, we review the recent advancements in the development of chitosan-based nanocomposites as a biocompatible carrier for drug delivery, specifically focusing on gene delivery, wound healing, microbial treatment, and anticancer drug delivery. By providing a valuable and up-to-date resource, this review illuminates the current state of research concerning chitosan's pivotal role in the biomedical domain as an efficacious drug delivery agent.