嵌合抗原受体
髓系白血病
癌症研究
白血病
髓系细胞
祖细胞
嵌合体(遗传学)
受体
抗原
髓样
免疫学
干细胞
医学
免疫疗法
生物
免疫系统
细胞生物学
内科学
基因
生物化学
作者
Taisuke Kondo,Naomi Taylor
标识
DOI:10.1016/j.ccell.2023.09.015
摘要
Chimeric antigen receptor (CAR) T cell therapies are limited by antigen escape and on-target/off-tumor toxicity. In addressing these challenges, Haubner et al. develop an “IF-BETTER” strategy. Their combinatorial chimeric co-stimulatory receptor with an attenuated CAR enhances acute myeloid leukemia (AML) killing while protecting healthy progenitors, highlighting the potential to leverage cooperative CAR designs.
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