Role of the substantia nigra pars reticulata in sleep-wakefulness: A review of research progress

Sleep is a complex physiological process that includes two main stages: non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. During mammalian sleep, especially REM sleep, skeletal muscles are suppressed to varying degrees, and corresponding movements are inhibited. The synchronous occurrence of sleep and motor inhibition suggests they may share the same neural circuits. Recently, the substantia nigra pars reticulata (SNr) has attracted attention for its potential dual role in regulating sleep-wake cycles and movement. In this review, the SNr's role is surveyed by examining existing research reports regarding its involvement in sleep-wake regulation and motor control. By focusing on the SNr, the goal is to shed light on its dual role intricacies and stimulate further inquiry into potential interactions between sleep and movement regulation, thus aiming to explore sleep-wake regulatory mechanisms and offer novel directions for subsequent scientific investigation.