Effects of Apigenin on the Apoptosis Index of Atherosclerosis

Abstract: Recently, apigenin has been widely studied for its antiatherosclerosis properties, but its mechanism remains to be further elucidated. This study aims to evaluate the expression of LOX-1, Bcl-2, and Bax in apigenin-treated atherosclerotic rats and to explore whether apigenin affect the expression of apoptotic genes. We analyzed the relationship between these 3 genes and atherosclerosis based on bioinformatics methods and conducted animal experiments on them. We used a fully automatic analyzer to analyze blood lipid levels and found that apigenin had a good effect on lowering blood lipids. Western blot was used to detect LOX-1 protein, and RT-qPCR was used to detect Bcl-2 and Bax mRNA.The fruit showed that apigenin treatment reduced LOX-1 gene expression while increasing the Bcl-2/Bax ratio. These studies provide an experimental basis for the development of apigenin as a new drug for the treatment of atherosclerosis.