蛋白质组
小分子
药物发现
计算生物学
鉴定(生物学)
原位
仿形(计算机编程)
生物
化学
纳米技术
生物信息学
生物化学
计算机科学
材料科学
植物
有机化学
操作系统
作者
Ying Su,Jingyan Ge,Biwei Zhu,Yu‐Guo Zheng,Qing Zhu,Shao Q. Yao
标识
DOI:10.1016/j.cbpa.2013.06.005
摘要
The identification of potential cellular targets of small molecules is important in biomedical research and drug discovery, but has been challenging due to a lack of proteome-based methods that enable direct investigation of small molecule-protein interaction in live cells. This review summarizes some of the recent advances in target identification of bioactive molecules (including drugs and natural products) using in situ methods for cell-based proteome profiling of potential on and off targets.
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