化学
黄药
甲苯
磺酰
烷氧基
噻唑
氢化钠
药物化学
亚甲基
有机化学
烷基
作者
Narasimhamurthy Rajeev,Toreshettahally R. Swaroop,Seegehalli M Anil,Yadaganahalli K. Bommegowda,Kanchugarakoppal S. Rangappa,M. P. Sadashiva
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2017-07-13
卷期号:28 (17): 2281-2284
被引量:18
标识
DOI:10.1055/s-0036-1590811
摘要
Sodium hydride-induced cyclization of 1-[(isocyanomethyl)sulfonyl]-4-methylbenzene or ethyl isocyanoacetate with various xanthate esters gave 5-alkoxy-4-tosylthiazoles or ethyl 5-alkoxythiazol-4-ylcarboxylates, respectively, in good to excellent yields. The xanthate ester S-methyl O-phenyl dithiocarbonate gave 5-(methylsulfanyl)-4-tosyl-1,3-thiazole when treated with 1-[(isocyanomethyl)sulfonyl]-4-methylbenzene under similar conditions.
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