Binding of FUN14 Domain Containing 1 With Inositol 1,4,5-Trisphosphate Receptor in Mitochondria-Associated Endoplasmic Reticulum Membranes Maintains Mitochondrial Dynamics and Function in Hearts in Vivo

We conclude that FUNDC1 binds to IP₃R2 to modulate ER Ca²⁺ release into mitochondria and cytosol. Further, a disruption of the FUNDC1 and IP₃R2 interaction lowers the levels of Ca²⁺ in mitochondria and cytosol, both of which instigate aberrant mitochondrial fission, mitochondrial dysfunction, cardiac dysfunction, and heart failure.