基质
医学
阶段(地层学)
比例危险模型
间质细胞
卵巢癌
肿瘤科
舱室(船)
单变量分析
内科学
临床意义
病理
癌
多元分析
卵巢癌
免疫组织化学
癌症
生物
地质学
古生物学
海洋学
作者
Alexandre Labiche,Natacha Heutte,Paulette Herlin,Jacques Chasle,Pascal Gauduchon,Nicolas Elie
出处
期刊:International Journal of Gynecological Cancer
[BMJ]
日期:2010-01-01
卷期号:20 (1): 28-33
被引量:60
标识
DOI:10.1111/igc.0b013e3181bda1cb
摘要
We investigated the prognostic significance of stromal compartment on the overall survival of patients with advanced epithelial ovarian cancer.We evaluated retrospectively the stroma proportion of the tumor surgical specimens of 194 patients with stages III and IV disease, using histochemical staining and fully automatic virtual slide processing. The prognostic significance of stroma proportion and clinical parameters were evaluated using log-rank test and Cox regression.Stroma proportion was found to be an independent prognostic factor by both univariate (P = 0.016) and multivariate analyses (hazards ratio = 1.45, P = 0.011).The present data indicate that a high stroma proportion is related to a poor prognosis of stage III and IV ovarian carcinomas.
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