Highly Efficient Synthesis of α‐Halomethylketones via Ce(SO4)2/Acid Co‐Catalyzed Hydration of Alkynes

Abstract A general atom‐economical approach for the synthesis of α ‐halomethyl ketones is demonstrated through Ce(SO 4 ) 2 /acid co‐catalyzed hydration of a wide range of haloalkynes. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in good to excellent yields, with broad substrate scope. This protocol is an alternative to conventional α ‐halogenation of ketones.