胶束
共聚物
超分子化学
化学
阿霉素
自组装
高分子化学
组合化学
聚合物
水溶液
有机化学
分子
医学
外科
化疗
作者
Xian Jun Loh,Jesús del Barrio,Pearl Pei Chern Toh,Tung‐Chun Lee,Dezhi Jiao,Urs Rauwald,Eric A. Appel,Oren A. Scherman
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2011-12-23
卷期号:13 (1): 84-91
被引量:169
摘要
The synthesis of a supramolecular double hydrophilic block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. This system is responsive to multiple external triggers including temperature, pH and the addition of a competitive guest. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) as a thermoresponsive block and poly(dimethylaminoethylmethacrylate) (PDMAEMA) as a pH-responsive block. Moreover, encapsulation and controlled drug release was demonstrated with this system using the chemotherapeutic drug doxorubicin (DOX). This triple stimuli-responsive DHBC micelle system represents an evolution over conventional double stimuli-responsive covalent diblock copolymer systems and displayed a significant reduction in the viability of HeLa cells upon triggered release of DOX from the supramolecular micellar nanocontainers.
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