化学
钯
分子内力
加合物
级联
迈克尔反应
组合化学
催化作用
乌吉反应
立体化学
作者
Chao Liu,Ruiqi Zhao,Liangliang Song,Zhenghua Li,Guilong Tian,Yi He,Luc Van Meervelt,Vsevolod A. Peshkov,Erik V. Van der Eycken
摘要
A palladium-catalyzed intramolecular cyclization of Ugi-adducts via a cascade dearomatization/aza-Michael addition process has been developed. Diverse plicamine analogues are constructed in a rapid, highly efficient and step-economical manner, through the combination of an Ugi-4CR and a palladium-catalyzed dearomatization. The synthetic utility of this approach is illustrated by further functional group transformations.
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