生物
核糖核酸
α病毒
RNA依赖性RNA聚合酶
RNA沉默
蟾蜍科
病毒复制
解旋酶
遗传学
RNA聚合酶
细胞生物学
病毒学
基因
病毒
RNA干扰
作者
Tero Ahola,Gerald M. McInerney,Andres Merits
出处
期刊:Advances in Virus Research
日期:2021-01-01
卷期号:: 111-156
被引量:25
标识
DOI:10.1016/bs.aivir.2021.07.003
摘要
Alphaviruses are positive-strand RNA viruses, typically transmitted by mosquitoes between vertebrate hosts. They encode four essential replication proteins, the non-structural proteins nsP1-4, which possess the enzymatic activities of RNA capping, RNA helicase, site-specific protease, ADP-ribosyl removal and RNA polymerase. Alphaviruses have been key models in the study of membrane-associated RNA replication, which is a conserved feature among the positive-strand RNA viruses of animals and plants. We review new structural and functional information on the nsPs and their interaction with host proteins and membranes, as well as with viral RNA sequences. The dodecameric ring structure of nsP1 is likely to be one of the evolutionary innovations that facilitated the success of the progenitors of current positive-strand RNA viruses.
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