医学
β-2微球蛋白
危险系数
荟萃分析
内科学
透析
肾脏疾病
纳入和排除标准
BETA(编程语言)
重症监护医学
置信区间
病理
计算机科学
程序设计语言
替代医学
作者
Jialing Zhang,Xiangxue Lu,Zhonghua Yuan,Han Li,Shixiang Wang
标识
DOI:10.1111/1744-9987.13729
摘要
The aim of this study was to delve into whether beta-2 microglobulin could assess all-cause mortality in patients with chronic kidney disease. PubMed and Embase were systematically searched. Hazard risk and 95% CI were pooled using random-effect models. A total of eight studies were involved according to the inclusion and exclusion criterions. By meta-analysis, each 1 mg/L increase in beta-2 microglobulin displayed positive relationships to the risk of all-cause mortality (hazard risk 1.03, 95% CI = 1.02-1.03) and cardiovascular events (hazard risk 1.04, 95% CI = 1.00-1.08) in patients with dialysis. However, the relationship between elevated level of serum beta-2 microglobulin as a categorical variable and mortality was not significant. The prognostic value of elevated beta-2 microglobulin might be significant in ESRD patients with dialysis and a proper cutoff value to predict mortality should be determined in the future.
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